| | Runs | playerId | seasonId | clubId | matchId | Runs | Player | Team | Season | Grade | Round | Inns | Opponent |
| 1 | 110 | 825575 | 154 | 4731 | 3702423 | 110 | Cooper Brien | St Stanislaus' College | 2021 | Division One | 1 | 1 | Oakhill College |
| 2 | 87 | 989803 | 154 | 4719 | 3702521 | 87 | Finn Gray | St Patrick's College | 2021 | Division One | 3 | 1 | St Gregory's College |
| 3 | 78 | 1402990 | 154 | 4719 | 3702424 | 78* | Cooper Edwards | St Patrick's College | 2021 | Division One | 1 | 1 | St Pius X College |
| 4 | 77 | 1048571 | 154 | 15604 | 3702427 | 77 | Angus V Griffin | Oakhill College | 2021 | Division One | 3 | 1 | St Augustine's College |
| 5 | 73 | 793890 | 154 | 4728 | 3702424 | 73 | Joe Colgan | St Pius X College | 2021 | Division One | 1 | 1 | St Patrick's College |
| 6 | 70 | 911220 | 154 | 4719 | 3702521 | 70* | Adam Brooks | St Patrick's College | 2021 | Division One | 3 | 1 | St Gregory's College |
| 7 | 69 | 989803 | 154 | 4719 | 3702424 | 69* | Finn Gray | St Patrick's College | 2021 | Division One | 1 | 1 | St Pius X College |
| 8 | 58 | 880160 | 154 | 15604 | 3702423 | 58 | Matthew Hurst | Oakhill College | 2021 | Division One | 1 | 1 | St Stanislaus' College |
| 9 | 56 | 969073 | 154 | 4731 | 3702423 | 56* | Hamish Gibson | St Stanislaus' College | 2021 | Division One | 1 | 1 | Oakhill College |
Note: Qualification levels for this report are 50 and 100 runs.
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